This book intends to reveal the latent purpose required to champion, lead, and enact digital transformation. It articulates that a purposeful approach, as followed in this book, is urgently required and may help the world’s population harness the power of technology. The book is based on over twenty years of the author’s research, thinking, discussions, publications, and observations about how technology influences us. He also builds upon his understanding of sciences–physics, chemistry, neuroscience, and others–to bring out the notion of purpose–the purpose of digital transformation. The book is a scientific endeavor to define and address the paradox surrounding digital technologies, framing it as a problem underlined due to unclarity in purpose. The lack of understanding of purpose may hurt individuals, organizations, and societies. The book, therefore, identifies purpose as a way to lead digital transformations. In doing so, it outlines complex and interwoven linkages between life, organization, and digital technologies. Thinking about digital technologies as an element devoid of links with life is dangerous. We are intertwined with technology today. So, to digitally transform, the books espouses a new way to look at ourselves and life, using the neuroscientific lens. Unraveling the linkages between the organization, life, and digital technologies, the book outlines a model for purposeful digital transformation.